IMPACT OF MATERNAL THYROID STATUS ON PREGNANCY AND FETAL AND CHILDHOOD DEVELOPMENT

Friday, April 2, 2004
Holiday Inn Old Town Select
Alexandria, Virginia

Sponsored by
Johns Hopkins University School of Medicine
A symposium of the
American Thyroid Association
and the
American Association of Clinical Endocrinologists

American Thyroid Association (ATA)

The ATA provides outstanding leadership in thyroidology by promoting excellence and innovation in clinical care, research, education, and public advocacy.

The American Thyroid Association national headquarters is at
6066 Leesburg Pike, Suite 650
Falls Church, VA 22041
Phone (703) 998-8890 / Fax (703) 998-8893
E-mail: thyroid@thyroid.org
Website: www.thyroid.org

American Association of Clinical Endocrinologists (AACE)

The American Association of Clinical Endocrinologists is a professional medical organization devoted to the enhancement of the practice of clinical endocrinology.

The American Association of Clinical Endocrinologists national headquarters is at
1000 Riverside Avenue, Suite 205
Jacksonville, FL 32204
Phone (904) 353-7878 / Fax (904) 353-8185
E-mail: info@aace.com
Website: www.aace.com

Course Description

Health care professionals caring for women of reproductive age or during pregnancy, particularly those women with known thyroid disorders; healthcare professionals caring for infants born to women with thyroid disorders. This includes primary care physicians (obstetrician-gynecologists, family medicine, and internists), sub-specialists (pediatric, adult, and reproductive endocrinologists, perinatologists, neonatologists and genetic counselors), specialists in human development (medical psychologists), epidemiologists and public health policy makers, and advocacy groups for maternal and child health.

Evidence is accumulating that maternal thyroid dysfunction has an untoward impact on fetal and childhood development. Maternal hypothyroidism is estimated to be 100 times more common than congenital hypothyroidism. There is a need for clinicians caring for women of reproductive age and during pregnancy to know which patients are at risk for thyroid dysfunction, and to know how to diagnose and manage thyroid disorders during pregnancy. This symposium will review normal thyroid function in healthy women and changes during pregnancy, discuss the prevalence and etiology of thyroid dysfunction during pregnancy, and review evidence of its adverse effect on pregnancy outcome and fetal and childhood development. This will include a discussion of the potential role of environmental toxins on thyroid function. The diagnosis and management of thyroid disorders during pregnancy will be reviewed, including a focus on whether at-risk patients can be identified and the potential benefits of population screening.

Objectives

Following this program, the participant should be able to:
• Describe the important changes in thyroid function that occur during pregnancy.
• List the most common causes of maternal hypothyroidism.
• Select appropriate thyroid diagnostic tests during pregnancy and interpret their results.
• Know factors to consider in the treatment of hypothyroidism and hyperthyroidism during pregnancy.
• Understand the implications of maternal hypothyroidism and hyperthyroidism on fetal outcome.

Accreditation

ACCREDITATION STATEMENT
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT
The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 7.5 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

American Academy of Family Physicians (AAFP)
This activity has been reviewed and is acceptable for up to 6.5 prescribed credits by the American Academy of Family Physicians.

Psychologists
The Johns Hopkins University School of Medicine is authorized by the State Board of Examiners of Psychologists as a provider of continuing education. Johns Hopkins University School of Medicine maintains responsibility for this program. A certificate for 7.5 CEUs will be awarded upon completion of this activity.

Americans with Disabilities Act
The Johns Hopkins University School of Medicine fully complies with the legal requirements of the ADA and the rules and regulations thereof. Please notify us if you have any special needs.
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Faculty

Stephen H. LaFranchi, MD
Professor, Department of Pediatrics - Endocrinology
Oregon Health & Science University
Portland, Oregon

Robert C. Smallridge, MD, FACE
Professor of Medicine
Mayo Medical School
Chair, Endocrinology Division
Mayo Clinic
Jacksonville, Florida

Brian M. Casey, MD
Associate Professor of Obstetrics and Gynecology
University of Texas SW at Dallas
Department of OB/GYN
Dallas, Texas

P. Reed Larsen, MD
Professor of Medicine
Harvard Medical School
Chief, Endocrinology Division
Brigham & Women's Hospital
Boston, Massachusetts

John H. Lazarus, MA, MD, FRCP, FACE
Professor of Clinical Endocrinology
University of Wales College of Medicine
LLandough Hospital
Cardiff, Wales, United Kingdom

Kenneth J. Leveno, MD
Gillette Professor of Obstetrics and Gynecology
University of Texas Southwestern Medical Center at Dallas
Chief of Obstetrics, Parkland Health and Hospital System

Gabriella Morreale de Escobar
Instituto de Investigaciones Biomedicas "Alberto Sols"
Madrid, Spain

Joanne Rovet, PhD
Senior Scientist
The Hospital for Sick Children Research Institute
Toronto, Canada

Carole A. Spencer, PhD, FACB
Professor of Medicine
University of Southern California
Director, USC Endocrine Services Laboratory
University of Southern California
Los Angeles, California

Gregory A. Brent, MD
Professor of Medicine and Physiology
David Geffen School of Medicine at UCLA
Chief, Endocrinology and Diabetes
Division VA
Greater Los Angeles Healthcare System
Los Angeles, California

Rosalind S. Brown, MD, CM
Associate Professor of Pediatrics
Harvard Medical School
Endocrine Division
Children's Hospital
Boston, Massachusetts

Thomas P. Foley, Jr., MD
Professor Emeritus
University of Pittsburgh
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania

Hossein Gharib, MD, FACE
Professor of Medicine
Mayo Clinic College of Medicine
Immediate Past President, American Association of Clinical Endocrinologists
Rochester, Minnesota

Daniel Glinoer, MD, PhD
Chief, Thyroid Investigation Clinic
University Hospital St. Pierre
Department of Internal Medicine
Brussels, Belgium

Joseph G. Hollowell, Jr., MD, MPH
Clinical Professor of Pediatrics
University of Kansas Medical Center
Kansas City, Kansas

Paul W. Ladenson, MD
Director of Endocrinology and Metabolism
Professor of Medicine, Pathology, and Oncology
Johns Hopkins University School of Medicine
Baltimore, Maryland

Susan J. Mandel, MD, MPH
Associate Chief for Clinical Affairs
Associate Professor of Medicine and Radiology
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania

Jorge H. Mestman, MD
Professor of Clinical Medicine and OB/GYN
Keck School of Medicine
University of Southern California
Los Angeles, California

Michael D. Shelby, PhD
Director, National Toxicology Program Center for the Evaluation of Risks to Human Reproduction
National Institute of Environmental Health Sciences
Research Triangle Park, North Carolina

Catherine Y. Spong, MD
Chief, Pregnancy and Perinatology Branch
National Institute of Child Health & Human Development
National Institutes of Health
Bethesda, Maryland

Alex S. Stagnaro-Green, MD
Professor of Medicine
Associate Dean for Curriculum and Faculty Development
UMDNJ-New Jersey Medical School
Newark, New Jersey

R. Thomas Zoeller, PhD
Professor of Biology
University of Massachusetts
Amherst, Massachusetts

Policy On Faculty And Provider Disclosure

It is the policy of the Johns Hopkins University School of Medicine that the faculty and provider disclose real or apparent conflicts of interest relating to the topics of this educational activity, and also disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentation(s). Detailed disclosure will be made in the course handout materials.

Meeting Location

Program