American Thyroid Association. Scientists & Physicians Dedicated to Better Understanding & Treatment of Thyroid Diseases.

ATA Thyroid Research Grant Recipients 1999

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The following represent thyroid-related publications from all ATA-supported grant recipients, arranged by the year the award was made, covering the five year period following the award.

1999

Michele Marino, MD-Massachusetts General Hospital/Harvard Medical School
“Megalin (gp330) in thyroid physiology and pathology”

1. Marino M, McCluskey RT 2000. Role of thyroglobulin endocytic pathways in the control of thyroid hormone release. Am J Physiol Cell Physiol 279:C1295-C1306.

2. Marino M, Chiovato L, Mitsiades N, Latrofa F, Andrews D, Tseleni-Balafouta S, Collins AB, Pinchera A, McCluskey RT 2000. Circulating thyroglobulin transcytosed by thyroid cells in complexed with secretory components of its endocytic receptor megalin. J Clin Endocrinol Metab 85:3458-3467.

3. Marino M, McCluskey RT 2000. Megalin-mediated transcytosis of thyroglobulin by thyroid cells is a calmodulin-dependent process. Thyroid 10:461-469.

4. Marino M, Zheng G, Chiovato L, Pinchera A, Brown D, Andrews D, McCluskey RT 2000. Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release. J Biol Chem 275:7125-7137.

5. Lisi S, Chiovato L, Pinchera A, Marcocci C, Menconi F, Morabito E, Altea MA, McCluskey RT, Marino M 2003. Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway. J Endocrinol Invest 26:1105-1110. ? OMIT

6. Marino M, Lisi S, Pinchera A, Chiovato L, McCluskey RT 2003. Targeting of thyroglobulin to transcytosis following megalin-mediated endocytosis: evidence for a preferential pH-independent pathway. J Endocrinol Invest 26:222-229.

Ann Marie Zavacki, PhD-Brigham and Women's Hospital/Harvard Medical School
“Regulation of thyroid hormone responsive genes by the nuclear receptor RIP 14"

1. Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC 2003. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol 17:2603-2612.

2. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC 2003. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest 112:189-196.

3. Curcio-Morelli C, Gereben B, Zavacki AM, Kim BW, Huang S, Harney JW, Larsen PR, Bianco AC 2003. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology 144:937-946.


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