Frailty is a condition seen in older adults and is defined when three or more of the following components are present: loss of muscle mass and strength, weakness, exhaustion, slowness and low activity. Subclinical thyroid dysfunction, which represents mild thyroid abnormalities, also increases with age and can cause similar problems. This study evaluated the potential association between subclinical thyroid dysfunction and frailty.
THE FULL ARTICLE TITLE:
Virgini VS et al; Osteoporotic Fractures in Men (MrOS) Research Group. Subclinical thyroid dysfunction and frailty among older men. J Clin Endocrinol Metab. October 23, 2015:jc20153191 [Epub ahead of print].
SUMMARY OF THE STUDY
A total of 1455 men ≥65 years of age from the Osteoporotic Fractures in Men Study (MrOS) were included in the study. TSH and free T4 levels were measured. A frailty assessment was based on the following five components: loss of muscle mass and strength, weakness, exhaustion, slowness and low activity. Participants with three components were classified as “frail,” those with 1 to 2 components as “intermediate,” and those with no component as “robust.” After 5 years, the participants who were still alive were reassessed.