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Thyroid®. 2026;0(0)

Thyroid®: Thyroid Hormone Synthesis Without Thyroglobulin

By | Featured, Thyroid Journal

Background: Heterozygosity of genetically encoded misfolded mutant thyroglobulin (TG, the thyroid hormone protein precursor) occurs with a frequency estimated at 1-in-217 people worldwide, resulting in subclinical hypothyroidism that largely escapes medical detection. However, patients carrying biallelic TG mutation, when untreated, are frankly hypothyroid unless and until they develop a massive goiter. To date, TG is the only proven endogenous precursor protein for thyroid hormone synthesis in vertebrates.

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Clinical Thyroidology for the Public

2025 ATA Differentiated Thyroid Cancer Guidelines: Completion Thyroidectomy- Clinical Thyroidology® for the Public

By | Clinical Thyroidology for the Public, Featured, Friends of the ATA

A significant change in the 2025 thyroid cancer guidelines is an increase in the recommendation of lobectomy. Prior guidelines indicate that completion thyroidectomy is considered in up to 20% of patients with a lobectomy and cancer >2 and ≤4 cm. This paper summarizes the changes in recommendations for completion thyroidectomy in the 2025 ATA differentiated thyroid cancer guidelines.

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Clinical Thyroidology for the Public

Development of a model to predict who will need to take a thyroid hormone pill after partial removal of the thyroid gland – Clinical Thyroidology® for the Public

By | Clinical Thyroidology for the Public, Featured, Friends of the ATA, Thyroid Surgery

The study authors reviewed the medical records for all patients who underwent partial thyroidectomy at their institution between 2013 and 2020. They identified 425 patients who met study criteria. The authors then identified which of these patients were prescribed levothyroxine after surgery.

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Clinical Thyroidology for the Public

Long-term safety of treatment options for hyperthyroidism: which is the best? – Clinical Thyroidology® for the Public

By | Clinical Thyroidology for the Public, Featured, Friends of the ATA

There are 3 treatment options for hyperthyroidism – antithyroid drugs, radioactive iodine therapy and thyroid surgery. There are various factors that go into deciding which treatment option to consider, including the underlying cause for hyperthyroidism, side effects of treatment and patient preferences. This study aimed to assess the long-term safety of each of the three options of treatment for hyperthyroidism.

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