The information about the age, body mass index, medical conditions, ethnicity, level of education, employment, smoking and use of illegal drugs, complications and course of pregnancy was obtained by reviewing medical charts The patients were divided into two groups; group 1 consisted of 85 women who had immediate increase of Levothyroxine dose after the thyroid blood test in first trimester of pregnancy showed abnormal TSH and group 2 consisted of 11 women who did not have any adjustment in levothyroxine dose. The rate of miscarriage and death of baby after 22nd week of pregnancy was compared between the two groups. Women who did not have any adjustment in Levothyroxine dose had a higher level of TSH in their last pregnancy blood test; 36% of women in this group had lost their pregnancy due to miscarriage. The rate of pregnancy loss was 2.4% in women who took a higher dose of thyroid hormone after pregnancy. No difference was found between the two groups in the rate of other pregnancy complications.
WHAT ARE THE IMPLICATIONS OF THIS STUDY?
The study confirms that the dose requirements for Levothyroxine increase during pregnancy and shows that an increase in the Levothyroxine dose early in pregnancy may prevent some cases of pregnancy loss and miscarriage. The result of this study is important for young women and their physicians and re-affirms the need for close monitoring of thyroid levels during pregnancy.
— Shirin Haddady, MD
ATA THYROID BROCHURE LINKS
Thyroid Hormone Treatment: http://www.thyroid.org/thyroid-hormone-treatment/
Thyroid Disease and Pregnancy: http://www.thyroid.org/thyroid-disease-pregnancy/