In patients who have had surgery (total thyroidectomy) for thyroid cancer, diagnostic whole body radioactive iodine (I-123 or I-131) scans are used to look for residual normal thyroid tissue or recurrent thyroid cancer that may be treated with radioactive iodine therapy. However, sometimes thyroid cancer lesions may be missed on traditional diagnostic radioactive iodine scans. In this study, a systematic review of the literature and pooled analysis of published data was performed, to determine how effective I-124 PET/CT is in identifying thyroid cancer lesions that may be able to be treated with radioactive iodine, as confirmed by a post-therapy scan (after radioactive iodine treatment).
THE FULL ARTICLE TITLE:
Santhanam P et al. Utility of I-124 PET/CT in identifying radioiodine avid lesions in differentiated thyroid cancer: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 2017 May;86:645-51. Epub February 28, 2017.
SUMMARY OF THE STUDY
The authors did an electronic search of MEDLINE/ PUBMED and EMBASE databases for relevant articles on the use of “I-124” and “differentiated thyroid cancer”, and then reviewed 118 published reports. The authors included 8 studies that met their criteria for the review. In these studies, I-124 PET/CT scans were performed prior to radioactive iodine treatment and the results were compared to the post-therapy scans.