Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status
Katleen Van Uytfanghe, Joel Ehrenkranz, David Halsall, Kelly Hoff, Tze Ping Loh, Carole A. Spencer, and Josef Köhrle; ATA Thyroid Function Tests Writing Group
PREFACE This document aims to provide a state-of-the-art status report on the progress achieved in thyroid testing, including thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3). The target audience for this document includes general practitioners, endocrinologists, and laboratory professionals. It is not a systematic review or a guidance document addressing currently encountered diagnostic and clinical challenges related to these three key parameters of thyroid testing (Box 1). It does not cover the use of thyroid antibodies for investigating the etiology of thyroid dysfunction, or the use of thyroglobulin as a tumor marker for differentiated thyroid cancer or the investigation of primary congenital or acquired hypothyroidism. Clinically relevant aspects of thyroid pathophysiology and the regulation of the hypothalamic-pituitary-thyroidperipheral axis have recently been reviewed elsewhere.1,2 Generic abbreviations for thyroid hormones (THs), T4 and T3, are used in this text, if both total and free TH are meant. Total T4 (TT4) and total T3 (TT3) are used for total and free T4 (fT4) or free T3 (fT3) for free TH concentrations, respectively. READ ARTICLE…
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