About 38% of Papillary thyroid cancer cases were multifocal. Patients with multifocal cancer had more extension of the cancer outside of the thyroid, more spread of the cancer to the lymph nodes in the neck and more advanced staging. More patients with multifocal cancers had radioactive iodine therapy and received a higher dose of radioactive iodine.
After considering all the known risk factors causing higher recurrence into analysis, the patients with multifocal cancers did not have a higher rate of recurrence of the cancer or spread of the cancer outside of the neck and did not have a higher death rate. In analysis of 89,680 patients fro SEER database also showed that multifocal thyroid cancers did not have a higher death rate.
WHAT ARE THE IMPLICATIONS OF THIS STUDY?
The conclusion of this study was that multifocal Papillary thyroid cancer is not associated with a higher death rate, recurrence or spread outside of the neck. Based on this finding, a higher dose of radioactive iodine and more aggressive treatment is not indicated for patients with multifocal Papillary thyroid cancer.
— Shirin Haddady, MD
ATA THYROID BROCHURE LINKS
Thyroid Cancer (Papillary and Follicular): https://www.thyroid.org/thyroid-cancer/
Radioactive Iodine: https://www.thyroid.org/radioactive-iodine/