Clinical Thyroidology for the Public summarizes selected research studies discussed in the previous month’s issue of Clinical Thyroidology, an official publication of the American Thyroid Association. Editor-in-chief, Alan Farwell, MD, FACE
Volume 12 Issue 6
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Clinical Thyroidology for the Public Volume 12 Issue 6 (PDF file, 6.4 MB)
TABLE OF CONTENTS – Web Format
MEDULLARY THYROID CANCER Patients with early-stage medullary thyroid cancer have similar survival to general population
Medullary thyroid cancer is a relatively rare type of thyroid cancer that often runs in families. Patients can do well if the cancer is detected early, but have a poor prognosis once it has spread beyond the thyroid. This study looks at risk factors for a bad prognosis in a subset of patients with medullary thyroid cancer.
Mathiesen JS et al C 2019 Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: a nationwide study. Thyroid. Epub 2019 Jan 31. PMID: 30618340.
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THYROID NODULES Can a standard scoring system of thyroid ultrasound findings accurately determine the need for a biopsy?
Several ultrasound-based risk stratification systems have been developed to determine which thyroid nodules should be referred for biopsy. The goal of this study was to compare the ability of the 5 most widely used ultrasound-based risk-stratification systems to identify nodules that do not need further evaluation with thyroid biopsy, without missing cancerous nodules.
Grani G et al 2019 Reducing the number of unnecessary thyroid biopsies while improving diagnostic accuracy: toward the “right” TIRADS. J Clin Endocrinol Metab 104:95–102. PMID: 30299457.
(PDF File for saving and printing, 279 KB)
THYROID CANCER Cancer rates in children with indeterminate thyroid nodules
Thyroid nodules are uncommon in children; however, the risk of cancer in a thyroid nodule is higher when compared to adults. Approximately 35% of thyroid nodules in children are reported as indeterminate by biopsy. The current ATA guidelines recommend surgery in children with indeterminate thyroid nodules. The objective of this study is to evaluate the cancer rate for indeterminate thyroid nodules in children.
Wang H et al Incidence and malignancy rates of indeterminate pediatric thyroid nodules. Cancer Cytopathology. Epub 2019 Feb 15. PMID: 30768868.
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HYPOTHYROIDISM Levothyroxine use following a partial thyroidectomy may increase the risk of osteoporosis
Some studies have shown an increased risk of osteoporosis after thyroidectomy, especially when patients are treated with high doses of levothyroxine as is done in patients with thyroid cancer. This present study was done to investigate the risk of osteoporosis after thyroid surgery of any kind.
Hung CL et al 2018 Is partial or total thyroidectomy associated with risk of long-term osteoporosis: a nationwide population-based study. World J Surg 42:2864–2871. PMID: 29541822.
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THYROID AND PREGNANCY High levels of thyroid antibody is associated with decreased response of thyroid gland to the main pregnancy hormone early in pregnancy
During pregnancy, the pregnancy hormone hCG stimulates the thyroid gland of pregnant mother to make more thyroid hormone, which is important for normal development of baby. However, if the mother has high levels of antibodies to thyroid gland, the thyroid gland may not respond as well to hCG. This study was done to assess response of thyroid gland to hCG in pregnant women with and without thyroid antibodies during the first 20 weeks of pregnancy.
Hou Y et al 2019 Different Thyroidal Response to Human Chorionic Gonadotropin Under Different Thyroid Peroxidase Antibody and/or Thyroglobulin Antibody Positivity Conditions During the First Half of Pregnancy. Thyroid 29(4):577-585
(PDF File for saving and printing, 381 KB)