Hypothyroidism is a common endocrine problem affecting mostly women. If untreated, it leads to impaired quality of life and function. The standard therapy for hypothyroidism, as recommended by the American Thyroid Association® (ATA), is synthetic levothyroxine, a safe and effective therapy. The US Food and Drug Administration (FDA) regulates levothyroxine medications to ensure bioavailability, dose equivalence, potency, and purity.