The L-T4 group had a 5% higher BMI and 5% less calorie intake adjusted by body weight than the matched control group, without any differences noted in type of food consumed. A higher proportion of the L-T4 group reported participation in moderate recreational activities as compared with the matched control group, although physical activity in general was lower in the L-T4 group. Additionally, in this group, more participants reported that their physical and mental health was not good as compared with the matched control group. Serum LDL, HDL, and total cholesterol were lower in the L-T4 group, while blood pressure, heart rate, glucose, HbA1c and triglycerides were similar in both groups.
WHAT ARE THE IMPLICATIONS OF THIS STUDY?
In this large population study, hypothyroid patients taking Levothyroxine who had a normal TSH level showed lower serum T3 and higher T4 levels, and consequently lower T3:T4 ratios than matched healthy individuals without thyroid problems. In addition, there were differences noted between the Levothyroxine– treated and healthy matched subjects in BMI, cholesterol levels, medications used as well as reported caloric intake, physical activity, and the feeling of poor health. These findings suggest that a normal TSH level may not be sufficient as a single criterion used to find the right levothyroxine dose for each patient.
— Alina Gavrila, MD, MMSC
ATA THYROID BROCHURE LINKS
Thyroid Function Tests: http://www.thyroid.org/ thyroid-function-tests/
Hypothyroidism (Underactive): http://www.thyroid.org/ hypothyroidism/
Thyroid Hormone Treatment: http://www.thyroid.org/ thyroid-hormone-treatment/