SUMMARY OF THE STUDY
The authors examined biopsy specimens from 261 nodules that were operated on at the University of Minnesota Medical Centre between Jan 2013 and Dec 2014. A total of 125 nodules (48%) were found to be malignant. A total of 102 surgeries (39%) were performed on indeterminate thyroid nodules (73 ASUS/FLUS, 29 SFN). The cancer rate of ASUS/FLUS nodules was 30% and the cancer rate of SFN nodules was 28%.
The Thyroseq™ Next Generation panel testing was performed on 44 of the 73 nodules in the ASUS/FLUS category and was found to have a sensitivity of 85%, specificity of 65%, positive predictive value of 50% and negative predictive value of 91%. Mutational testing was performed on 12 of the 29 nodules in the SFN category and was found to have a sensitivity of 100%, specificity of 57%, positive predictive value of 63% and negative predictive value of 100%. Overall, Thyroseq™ Next Generation panel testing of biopsy specimens was more likely to be positive in nodules that were proven to be cancerous compared with those that were benign.
WHAT ARE THE IMPLICATIONS OF THIS STUDY?
The results from this study indicate that mutational testing using the Thyroseq™ Next Generation panel may be helpful in managing indeterminate thyroid nodules. A negative test is very accurate in identifying a nodule as benign and, thus, avoiding surgery. The use of mutational testing on indeterminate thyroid nodules should be done on a regular basis to help determine the need for surgery in these nodules.
— Phillip Segal, MD
ATA THYROID BROCHURE LINKS
Thyroid Nodules: http://www.thyroid.org/ thyroid-nodules/
Thyroid Cancer (Papillary and Follicular): http://www.thyroid.org/thyroid-cancer/
Thyroid Cancer (Medullary): http://www.thyroid.org/medullary-thyroid-cancer/