2017 ATA Grant
Jason E. Coleman, PhD – University of Florida, Gainesville, FL
Effects of Early Hypo- and Hyperthyroidism on Long-term Cortical
Dr. Jason Coleman of the University of Florida was awarded a 2017 thyroid research grant for the project titled “Effects of Early Hypo- and Hyperthyroidism on Long-term Cortical Circuit Plasticity” by the American Thyroid Association. The grant was funded by the American Thyroid Association. Dr. Coleman has over 10 years of experience in research investigating the visual system and in the development and use of viral vectors for gene transfer for studying the nervous system. Dr. Coleman obtained his PhD in Neuroscience at the University of Florida (UF) where he conducted his thesis research focused on developing a lentiviral vector for the successful treatment of a form of inherited retinal blindness in a chicken model. He went on to perform his postdoctoral research in the laboratory of Professor Mark Bear at MIT, where his studies focused on investigations of visual circuitry in the mouse and of the contribution of axon remodeling to rapid experience-dependent plasticity in the visual cortex. While at MIT, he developed a paradigm for labeling and imaging specific subsets axons and synapses in vivo and helped design a two-photon tailored for chronic in vivo imaging of neurons. Dr. Coleman was recently recruited to UF. As a newly established PI in Pediatrics and the Child Health Research Institute at UF, he has established a successful research program studying the effects of perinatal insults on long-term neural structure and function and has already obtained competitive funding from the NIH and NSF.
Marco Medici, MD, PhD, MS – Erasmus Medical Center, Rotterdam, The Netherlands
Personalized management of thyroid disease
Dr. Marco Medici of the Erasmus Medical Center was awarded a 2017 thyroid research grant for the project titled “Personalized management of thyroid disease” by the American Thyroid Association. The grant was funded by the American Thyroid Association. Dr. Medici’s research focuses on the genetic basis of the HPT axis, as until recently only a limited number of genetic variants associated with thyroid function had been identified. In order to perform large-scale genetic studies, he initiated an international consortium, which now includes 34 centers with available (epi)genetic and thyroid function data in >80,000 participants. They have identified many new genetic determinants of thyroid function. After he finished his PhD (Cum Laude) in 2014, he subsequently did a postdoctoral research fellowship at the Harvard Institutes of Medicine and Brigham and Women’s Hospital in Boston, USA. He is currently a clinical fellow in Endocrinology and actively leading the research which forms the basis for his funded thyroid research project. The ATA thyroid research grant will enable him to take the next important step in his career which is to establish his first own independent line of translational research.
Lawrence Shirley, PhD – The Ohio State University, Wexner Medical Center, Columbus, OH
Impact of BRAF-mutated Papillary Thyroid Cancers on Cancer-Associated Fibroblast Genotype and Phenotype
Dr. Lawrence Andrew “Drew” Shirley MD, MS, FACS of the Ohio State University was awarded a 2017 thyroid research grant for the project titled “Impact of BRAF-mutated Papillary Thyroid Cancers on Cancer-Associated Fibroblast Genotype and Phenotype” by the American Thyroid Association. The grant was funded by the American Thyroid Association. Dr. Shirley is an Assistant Professor in the Division of Surgical Oncology at The Ohio State University Wexner Medical Center, and is the Associate Program Director of the Surgical Oncology Fellowship. Dr. Shirley received his BA in English/Molecular Biology at Vanderbilt University and MD from the University of Kentucky College of Medicine. He went on to complete his General Surgery Residency at Thomas Jefferson University Hospital, and a Surgical Oncology Fellowship at The Ohio State University. While in Fellowship, he also received a Masters in Medical Science. He joined the faculty at Ohio State University in October 2014. He is board certified in general surgery and complex general surgical oncology. His clinical practice focuses on the surgical management of endocrine disease, including thyroid, parathyroid, and adrenal diseases. His basic science laboratory focuses on the role of cancer-associated fibroblasts in thyroid cancer as a method to both develop novel biomarkers to guide treatment as well as uncover novel therapeutic targets for more aggressive variants of this cancer type.
2016 ATA Grant
Dr. Liora S. Katz is an Instructor at the Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai. Her research fields include diabetes, obesity and the role of thyroid hormones in cell differentiation. Dr. Katz combines in her research molecular biology, biochemistry, epigenetics, pharmacology, physiology and cell biology approaches. Her endocrinology research was published in a variety of scientific peer reviewed journals and she has presented her data in numerous international conferences. She has successfully written fellowship grants and won scientific awards from the American Thyroid Association, International Endocrine Society, National Institutes of Health, Swiss National Foundation (three times) and Servier Pharmaceutical Company. Dr. Katz completed her post-doctoral training at the Laboratory of Endocrinology and Receptor Biology at the National Institutes of Health. She holds a PhD from the department of Endocrinology, Diabetes and Nutrition, Geneva University, Switzerland and MSc in biological chemistry and BSc degree in biology from the Hebrew University of Jerusalem, Israel. Press Release
Dr. Connie Rhee is a nephrologist and early-career clinical investigator with a strong commitment to studying the interaction between thyroid functional disorders and kidney disease. She is a graduate of the Brigham and Women’s Hospital/Massachusetts General Hospital joint nephrology fellowship program and the Harvard School of Public Health Master’s of Science in Epidemiology program, and she is currently an Assistant Professor of Medicine at the University of California Irvine School of Medicine. Over the past six years, Dr. Rhee has conducted pioneering research showing that thyroid functional disease is highly prevalent in chronic kidney disease patients, and that hypothyroidism is associated with higher mortality risk in kidney disease populations while supported by an NIH F32 Postdoctoral Fellowship Award (2011-2012) and currently by an NIH K23 Career Development Award (2014-2019). Dr. Rhee ultimately aspires to become an independent NIH R01-funded investigator bridging the fields of endocrinology and kidney disease, and to develop a world-class research center devoted to 1) advancing our understanding of the interaction between endocrine disorders and kidney disease, 2) serving as a hub for other scientists in endocrinology and nephrology with expertise in clinical, translational, and basic science investigation, and 3) training the next generation of young investigators. Press Release
Dr. David Sharlin received his Bachelor’s of Science in Zoology from University of New Hampshire in 1999. In 2002, Dr. Sharlin joined the lab of Dr. Tom Zoeller at the University of Massachusetts where he completed his Ph.D in Molecular and Cellular Biology. His dissertation was focused on understanding the role of thyroid hormone in gliogenesis and myelination with an additional focus centered on understanding whether environmental chemicals could alter thyroid hormone mediated gliogenesis and myelination. Upon completing his Ph.D. 2007, Dr. Sharlin joined the laboratory of Dr. Douglas Forrest at the National Institutes of Health where he studied the role of thyroid hormone in sensory system development with a focus on role of thyroid hormone transporters in cochlear development. In August 2012, Dr. Sharlin accepted a tenure-track assistant professor appointment at Minnesota State University. The overall goal of Dr. Sharlin’s laboratory is to understand the molecular and cellular basis of neurocognitive and auditory deficits associated with insufficient thyroid hormone during development. The lab is also investigating mechanisms by which endocrine disrupting chemicals may interfere with thyroid hormone mediated development of the nervous system. Press Release
Kristen R. Vella, PhD is an Instructor at Beth Israel Deaconess Medical Center and Harvard Medical School. Dr. Vella received her undergraduate degree from MIT and her PhD from the University of Massachusetts Amherst. She was a postdoctoral fellow in the laboratory of Dr. Anthony Hollenberg at Beth Israel Deaconess Medical Center.
Dr. Vella’s research focuses on the molecular mechanisms underlying thyroid hormone regulation by metabolic signaling, particularly through the central hypothalamic axis and peripheral tissues such as the liver. She investigates the neurons necessary and sufficient to maintain thyroid hormone levels using transcriptomics and chemogenetics. Her work detailing the role of arcuate neuropeptide Y neurons on the hypothalamic-pituitary-thyroid axis was recently presented at ENDO 2016.
Dr. Vella was a previous member of the ATA’s Trainee and Career Advancement Committee and now serves on the ATA Internet Communications Committee. Press Release
Jonathan Wasserman, MD, PhD – Hospital for Sick Children,
Genetic Variants Underlying Isolated Hyperthyrotopinemia: A Pilot Prevalence Study from a Provincial Newborn Screening Cohort
Jonathan Wasserman is a Clinician-Investigator and Staff Endocrinologist at The Hospital for Sick Children in Toronto, Canada. Dr. Wasserman obtained his PhD from the University of Cambridge, prior to pursuing clinical training at Harvard Medical School and the Massachusetts Institute of Technology. He subsequently completed post-doctoral training in Endocrine Cancer Genetics with Dr. David Makin, where he studied at genetic variants underlying the pathogenesis of pediatric adrenocortical carcinoma. He was the recipient of a Lawson Wilkins Pediatric Endocrine Society Research Fellowship Award, a Canadian Pediatric Endocrine Group fellowship and a Canadian Child Health Clinician Scientist Program Post-Doctoral training award. Dr. Wasserman’s current research focuses on clinical and translational aspects of pediatric thyroidology including management of neonatal Graves’ disease, health service utilization among pediatric thyroid carcinoma survivors and genome-wide alterations in pediatric nodular thyroid disease.
Sungro Jo, PhD – Rush University Medical Center,
What are the mechanisms underlying the phenotype of Thr92Ala type II deiodinase (D2)?
The goal of the proposed research is to investigate the role of human polymorphism of type II deiodinase (D2) and its effect on thyroid hormone metabolism. Specifically, we plan to identify biochemical and cell biological mechanism underlying the D2 poly-morphic phenotype. I have the expertise, leadership and motivation necessary to suc-cessfully carry out the proposed work. I have a broad background in biochemistry and cell biology, with specific training and expertise in the key research areas for this ap-plication; I completed my postdoctoral training in 2008 studying cell biology of glucose transporters (GLUT4) focused on Akt signaling at Morris Birnbaum’s lab at University of Pennsylvania. I have been working with Dr. Antonio Bianco for the past 5 years to working on thyroid hormone metabolism focusing on deiodinase and published two first author articles on cell biology of D2 and D3. To continue my work with Dr. Bianco, I recently moved from the University of Miami to Rush University Medical Center where I am a staff scientist on his team. Press Release
Andrea Reyna-Neyra, PhD – Yale University,
New Haven, CT
The role of the renal Na+/I- symporter (NIS) in iodide metabolism and thyroid function
Dr. Andrea Reyna-Neyra, an Associate Research Scientist/Scholar in the Department of Cellular and Molecular Physiology at the Yale School of Medicine, received her Ph.D. in Biomedical Sciences from the National Autonomous University of Mexico. During her initial postdoctoral training at the Albert Einstein College of Medicine, she focused her scientific efforts on studying the genomic and non-genomic effects of steroid hormones on the central nervous system of rodents. Responding to her keen interest in endocrinology, and particularly thyroidology, she joined the laboratory of Dr. Nancy Carrasco, where she has been studying the role of the Na+/I- symporter (NIS) in physiology and pathophysiology, including its expression in tissues other than the thyroid. She participated in demonstrating that the environmental pollutant perchlorate (ClO4-) is actively transported by NIS, and that NIS mediates this translocation with a 1Na+:1ClO4- stoichiometry rather than the 2 Na+:1 anion stoichiometry that characterizes NIS-mediated I- transport. This was the first time that a transport protein was shown to translocate different substrates with different stoichiometries. Dr. Reyna-Neyra has also studied the interaction between NIS and the KCNQ1-KCNE2 potassium channel complex critical in cardiac function. Transporter-channel interactions were previously unknown, and in 2009, the NIS/KCNQ1-KCNE2 interaction was named the “Mechanism of the year in thyroidology”. Dr. Reyna-Neyra has characterized the molecular requirements that must be met for NIS to transport I- and other substrates, such as ClO4- and perrhenate (ReO4-). Furthermore, guided by mutations in patients with congenital I- transport defects, she has identified amino acid substitutions in NIS that change the substrate specificity and stoichiometry of the protein. These are pioneering contributions to the fields of thyroidology and membrane proteins
Tatiana de Lourdes Fonseca, PhD – Rush University Medical Center, Chicago, IL
What is the Role of Type II Deiodinase (D2)-Mediated T3 Production in Liver and its Repercussion to Energy Expenditure?
Tatiana Fonseca, PhD is a Staff Scientist in the Division of Endocrinology and Metabolism at Rush University Medical Center. Tatiana Fonseca earned her undergraduate degree in Physiotherapy at Pontifícia Universidade Católica of Minas Gerais, Brazil. She obtained her PhD in Morphofunctional Sciences from the Department of Anatomy at the University of Sao Paulo, Brazil where she worked with Dr. Cecília Gouveia studying the interaction of the sympathetic nervous system with thyroid hormone in the regulation of bone mass and metabolism. She completed her postdoctoral training in March of 2014 in the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine under the mentorship of Dr. Antonio Bianco. She has been working with Dr. Bianco for the past 4 years to develop tissue-specific knockout models to study the deiodinases. Recently, she moved from the University of Miami to Rush University Medical Center where is a staff scientist on Dr. Bianco’s team. Currently she is investigating the role of type II deiodinase (D2)-mediated T3 production in liver and its repercussion to energy expenditure.
Leo Kim, MD, PhD – Massachusetts Eye and Ear Infirmary, Boston, MA
Animal Models of Acute and Chronic Thyroid Eye Disease
Dr. Leo Kim received his M.D. and Ph.D. at Yale University as a member of the NIH-sponsored Medical Scientist Training Program. He completed his residency and fellowship in Ophthalmology and Retina and Vitreous Surgery at the Doheny Eye Institute at the University of Southern California. He is a practicing retinal specialist in the Department of Ophthalmology at the Massachusetts Eye and Ear Infirmary, Investigator at Schepens Eye Research Institute, and Instructor in Ophthalmology at Harvard Medical School. He is member of the Harvard K12 clinician scientist program and dedicates the majority of his time towards basic science research. His research is focused primarily on vasculogenesis and his interest in thyroid eye disease stems from the realization that both the retina and orbital tissues contain blood vessels, but lack lymphatic vessels. Lymphatic vessels play a critical role in draining interstitial fluid from tissues. His research proposal attempts to evaluate the molecular mechanisms underlying the lack of lymphatic vessels within the orbit and to test the hypothesis that the lack of lymphatic vessels within the orbit is involved in the pathogenesis of thyroid eye disease.
Peter Taylor MB, ChB – Cardiff University, United Kingdom
The Impact of Maternal and Offspring Genetic Variants on Phenotypic Outcomes in the Controlled Antenatal Thyroid Screening Study (CATS).
Peter Taylor, is a Welsh Clinical Academic Trainee in Diabetes and Endocrinology. Dr Taylor obtained his medical degree from the universities of St. Andrews and Manchester and developed a keen interest in thyroid research as an SHO at the Edinburgh Royal Infirmary under Dr. Toft. Since commencing his specialist training in diabetes and endocrinology, he has in parallel pursued a career in research and under the guidance of Professor Dayan, was awarded a MRC scholarship to study a MSc in epidemiology at the London School of Hygiene and Tropical Medicine.
From research awards he has performed full thyroid function in over 4,500 children in the internationally renowned birth cohort the Avon Longitudinal Study of Parents and Children, creating the largest European dataset of children with thyroid function who also have extensive genetic and phenotypic data. Interrogation of this dataset and the Clinical Practice Research Data-link (a large UK primary care database) is the focus of his research. This work has already resulted in 2 key publications in JCEM and another in JAMA internal medicine as well as several oral and poster presentation awards at national and international conferences. He also recently jointly undertook the first UK national survey of the management of amiodarone induced thyrotoxicosis and received the highest scoring clinical abstract award at the British Endocrine Society annual conference with his work on the impact of thyroid hormone bioavailability on childhood IQ.
W. Edward Visser, MD – Erasmus University Medical Center, Netherlands
Thyroid Hormone and Aging
After receiving his MD, Dr. Visser joined the laboratory of prof. Theo Visser at the Erasmus Medical Center(Rotterdam, The Netherlands), where he researched various aspects of local thyroid hormone regulation, in particular the role of thyroid hormone transporters. After obtaining his PhD, he started residency training in the Dept of Internal Medicine. As a postdoctoral fellow, Dr Visser studied the mechanisms of resistance to thyroid hormone due to thyroid hormone receptor alpha mutations in the laboratory of prof. Krish Chatterjee (University of Cambridge, UK). Currently, he is completing his endocrinology fellowship at the Erasmus Medical Center. During recent years, Dr Visser has started studies of thyroid hormone regulation in models of normal and premature aging. The 2014 ATA Grant enables Dr Visser to pursue these findings and may contribute to develop therapeutic strategies to promote healthy aging.
2013 ATA Grants
The Contribution of Cyp7a1 To The Cholesterol Lowering Actions Of TR Agonists
Kevin Phillips, PhD
Methodist Hospital – Houston, TX
Kevin Phillips, PhD pursued his doctoral research at Harvard University, working in the field of chemical biology. He then moved to San Francisco for postdoctoral training under the direction of John Baxter and Robert Fletterick at the University of California at San Francisco. In 2012 he became an independent investigator at The Methodist Hospital Research Institute in Houston. Dr. Phillips group studies the anti-obesogenic actions of thyroid hormone and its receptors, the thyroid hormone receptors (TRs). Obesity, an accelerating worldwide health problem, tends be accompanied by co-morbitidies that are often referred to as metabolic syndrome. Activation of TRs, either by endogenous thyroid hormone or by synthetic TR agonists, elicits catabolic processes that tend to oppose the maladies of metabolic syndrome. Dr. Phillips’ group is working to establish the molecular mechanisms by which the TRs mediate these clinically useful actions that include: the reduction of serum cholesterol and lipid levels, the amelioration of fatty liver disease, improved insulin sensitivity, and fat loss. A key interest is of his laboratory is understanding how TR activation mediates thermogenesis – the conversion of excess energy (such as extra calories or fat) to heat. In work that is ongoing, his group has discovered a novel mechanism by which TR agonists elicit thermogenesis, leading to dramatic fat loss in preclinical models of severe obesity. They are currently working to identify the molecular events that mediate this action and are exploring the beneficial physiological effects that accompany thermogenic induction. Press Release
What is the role of type II deiodinase (D2)-mediated T3 production in skeletal muscle
Joao Pedro Saar Werneck-de-Castro, PhD
University of Miami – Miami, Florida
Dr. João Pedro Werneck-de-Castro, PhD is a researcher associated of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. After obtaining his PhD in 2006 in human physiology at Federal University of Rio de Janeiro (UFRJ) working with cardiovascular physiology he became a junior faculty at UFRJ in 2007 at the School of Physical Education and Sports. Then, he started to study exercise physiology and biochemistry to understand the mechanisms of skeletal muscle induced-adaptations by exercise and the contribution of hormones to such adaptations. Currently he is investigating the pathways by which thyroid hormones regulates skeletal muscle physiology and the role of type-2 deiodinase in muscle biology and its importance to plasma T3 pool. Press Release
TXNIP as a Regulator of Thyroid Cancer Aggressiveness
Jennifer Morrison, MD, PhD
University of Colorado – Aurora, CO
Jennifer Morrison, M.D., Ph.D. is a Fellow Instructor in the Division of Endocrinology, Diabetes, and Metabolism at the University of Colorado Denver. She earned her Ph.D. degree in 2004 and her M.D. degree with distinction in 2006 through the Medical Scientist Training Program at the University of North Carolina- Chapel Hill. During this time, she published three first-author manuscripts in peer-reviewed journals detailing her research on Epstein-Barr virus-associated malignancies under the direction of Nancy Raab-Traub, Ph.D. at the Lineberger Comprehensive Cancer Center at UNC. She then completed her residency in Internal Medicine at UNC Hospitals, where she received awards for academic proficiency as well as peer-selected awards recognizing her empathic nature and bedside manner. In 2013, she completed her Endocrinology fellowship training at the University of Colorado. During fellowship, she was awarded an Endocrine Fellows Foundation Endocrine Research Grant as well as a Ruth L. Kirschstein National Research Service Award for Individual Postdoctoral Fellows. She is currently working in collaboration with Bryan R. Haugen, M.D. in the area of advanced thyroid oncology with particular interest in understanding the molecular mechanisms which underlie the development of aggressive thyroid cancers. Press Release
2012 ATA Grants
An investigation of the LDLR-independent serum lipid modulation by thyroid hormone
Stephen Ayers, PhD
The Methodist Hospital Research Institute, Houston, Texas
Dr. Ayers received his Ph.D. in Biochemistry from the Division of Nutritional Sciences at Cornell University, Ithaca, in 2007, where he researched the mechanisms of nuclear hormone receptor regulation. He then pursued postdoctoral studies on chromatin regulation at Lawrence Berkeley National Laboratory under the guidance of Terumi Kohwi-Shigematsu, Ph.D. Since then, he has studied the mechanisms of metabolic gene regulation by thyroid hormone in the Department of Genomic Medicine at Methodist Hospital Research Institute, under the leadership of John Baxter, MD and Paul Webb, Ph.D. This work has led to the project of his current proposal, focused on the investigation of serum lipid regulation, which he will pursue over the next two years. Dr. Ayers holds a Master’s degree in Bioinformatics from the University of Glasgow, Scotland, and a BA from Union College in Schenectady, NY.
Type 3 Deiodinase in Dilated Heart Failure
Ari J Wassner, MD
Children’s Hospital Boston, Boston, Massachusetts
Dr. Wassner received his B.A. in Chemistry and Spanish from Haverford College in Haverford, Pennsylvania. After earning his M.D. from Harvard Medical School, he completed residency training and chief residency in Pediatrics at Children’s Hospital Boston, followed by clinical fellowship in Pediatric Endocrinology at the same institution. As a postdoctoral fellow, Dr. Wassner joined the laboratory of Dr. Stephen Huang at Children’s Hospital Boston to study the role of deiodination and thyroid hormone metabolism in illness, work that he continues as a recently appointed Instructor in Pediatrics at Harvard Medical School. Dr. Wassner’s clinical focus is on the management of pediatric thyroid disease, with a special emphasis on the care of children with thyroid neoplasia.
2011 ATA Grants
Elucidating the in vivo Mechanisms by Which Thyroid Hormone Regulates Energy Expenditure
Inna Astapova, PhD
Beth Israel Deaconess Medical Center (Harvard Medical School) Boston, Massachusetts
Dr. Astapova is a native of Moscow, Russia, and received her M.S. in Physiology from Lomonosov Moscow State University, Moscow. She conducted her graduate studies at Engelhardt Institue of Molecular Biology, Russian Academy of Sciences, and received a Ph.D. in Molecular Biology in 2002. Soon after that Dr. Astapova joined laboratory of Dr. Anthony N. Hollenberg at Beth Israel Deaconess Medical Center in Boston as a postdoctoral fellow, and, recently, Instructor in Medicine, to study the role of nuclear corepressors NCoR and SMRT in the transcriptional repression by thyroid hormone receptor. Her research interests include not only the molecular basis of thyroid hormone action, but also the role of thyroid hormone in the regulation of metabolism and energy homeostasis, and potential use of thyroid hormone and its analogs for treatment of obesity and metabolic disease. Press Release
Role of interferon alpha in development of AITD: Epigenetic regulation of key genes
Mihaela Stefan, PhD
Mount Sinai School of Medicine New York, New York
Dr. Mihaela Stefan completed her undergraduate studies at University of Bucharest, Romania (1990 -1995). She obtained the doctoral degree in Genetics from the same institution in 2000. As a graduate student she was the recipient of several fellowships that allowed her to work in a well-known human genetics laboratory at Tor Vergata University in Italy. She spent her post-doctoral training at University of Pennsylvania (2001 – 2005). In 2005 she was appointed as Research Assistant Professor at University of Pittsburgh were she worked until 2009 when she was appointed as Assistant Professor at Mount Sinai School of Medicine in New York. Her current interests focus on the genetic and epigenetic mechanisms and genes underlying the clinical phenotype in thyroiditis. She has received honors and awards for the following; 2002 Postdoctoral Translational Award Winner from the American Society of Human Genetics, the American Heart Association Postdoctoral Fellowship Award (2003-2005) and the 2004 Postdoctoral Translational Award Finalist from the American Society of Human Genetics. Press Release
2010 ATA Grants
Regulation of Presympathetic Neuronal Activity by Thyroid Hormone
Jens Mittag, PhD
Karolinska Institutet Stockholm, Sweden
Jens Mittag PhD was born in Duisburg (Germany) in 1978 and grew up in Muenster (Germany). He received his diploma and his PhD in biochemistry from the University of Hannover (Germany) in 2003 and 2006 respectively. From 2007 he was a postdoctoral fellow in the lab of Björn Vennström at the Karolinska Institute in Stockholm (Sweden) funded by a longterm fellowship from EMBO and the German Research Council DFG. In 2010 he became Assistant Professor and junior group leader at the department of Cell and Molecular Biology at the Karolinska Institute, where he also completed his Associate Professorship in Endocrinology in 2011. His primary research interests are the central effects of thyroid hormone in comparison with its well-known peripheral effects.
2009 ATA Grants
Modeling BRaf-dependent thyroid cancer in the mouse
David G. McFadden, MD, PhD
Thyroid Associates, Boston, Massachusetts
David McFadden is an Instructor in Medicine at Harvard Medical School and the Massachusetts General Hospital Thyroid Unit and a Postdoctoral Associate at the Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research in the laboratory of Dr. Tyler Jacks. He graduated summa cum laude from Texas A&M University and subsequently obtained his MD, PhD degrees at UT Southwestern Medical Center where he studied tissue-specific transcription factors using genetically engineered mice in the laboratory of Dr. Eric N. Olson. He completed internship and residency in internal medicine at Brigham and Women’s Hospital and subsequently trained in endocrinology at the Massachusetts General Hospital under the mentorship of Dr. Gilbert Daniels. He maintains a weekly clinic in the MGH Thyroid Unit focused on the care of thyroid cancer patients. His research centers on the use of genetically engineered mice to study tumor progression, with an interest in mouse models of thyroid carcinoma. He received an ATA Research Award in 2009 that has partially supported his work to engineer novel mouse models of thyroid carcinoma.
Induction of Antigen-Specific Tolerance in Autoimmune Thyroiditis
Leonard Moise, ScB, PhD
University of Rhode Island, Providence, Rhode Island
Dr. Leonard Moise is a highly trained and skilled immune-biologist. Dr Moise enrolled at Brown University in 1993 and received his BS, PhD, as well as completed his post-doctoral training at Brown University. In 2005 he was became an Instructor of Medicine at Brown and in 2006 appointed Director of Vaccine Research for EpiVax, Inc. Dr. Moise has been actively involved in basic research including structural studies of neurotoxin action using NMR, computer based and experimental animal studies on vaccine design, and now more specifically on regulatory T cells in autoimmunity.
2008 ATA Grants
Role of Neurogranin in Hypothyroidism-induced Synaptic Plasticity Deficits
Nashaat Z. Gerges, PhD
Medical College of Wisconsin, Milwaukee, Wisconsin
Macrophage Causes Thyroid Diseases in LMP7 KO Mice: A New Spontaneous Thyroiditis Model
Hiroaki Kimura, PhD
The Johns Hopkins Medical Institutions, Baltimore, Maryland
Dr. Hiroaki Kimura is an assistant professor at Jichi Medical University, Center for Molecular Medicine, Division of Inflammation Research (Tochigi, Japan), studying thyroidal inflammation and metabolic diseases from 2010. He graduated and obtained his PhD at Nagoya City University, Graduate School of Pharmaceutical Sciences (Nagoya, Japan), studying transcriptional regulation of inflammatory cytokines. After he studied mycobacterial infection at the National Institute of Infectious Diseases (Tokyo, Japan), he joined Dr. Patrizio Caturegli’s lab as a post-doctoral fellow at the Johns Hopkins School of Medicine, Pathology and started a research in autoimmune thyroid diseases. He became a research associate and received an ATA research grant in 2008. He received Young Investigator Award from Asia Oceania Thyroid Association and Japan Thyroid Association in 2009.
2007 ATA Grants
Application of Reverse Genetics in the Identification of Defects in the Dual Oxidase Maturation Factor in Humans
Helmut Grasberger, MD
University of Chicago, Chicago, Illinois
Helmut Grasberger, MD currently holds the position of Research Assistant Professor as a member of the Endocrinology Section at the University of Chicago Medical Center. Dr. Grasberger attended Medical school at the Ludwig-Maximilians University in Munich, where he obtained his M.D. in 1998, and a Dr. med. summa cum laude for his work on structure-function studies of thyroxin-binding globulin in 2000. In the same year, he began his postdoctoral training at the Department of Biochemistry and Molecular Biology at the University of Chicago under the guidance of Dr. Graeme Bell, and in 2003 joined the Thyroid Study Unit as research associate in the laboratory of Dr. Samuel Refetoff. His recent original work includes the identification of a locus on chromosome 15 associated with the dominantly inherited resistance to TSH and the discovery of the long-sought gene encoding a maturation factor necessary for the activation of the hydrogen peroxide generating enzymes in the thyroid.
Thyroid Hormone, Type 2 Deiodinase, and Energy Expenditure in Human Skeletal Muscle
Brian Kim, MD
Brigham and Women’s Hospital, Boston, Massachusetts
Brian W. Kim is an assistant professor of medicine and Program Director in the Division of Endocrinology, Diabetes, and Metabolism at the University of Miami Miller School of Medicine. Dr. Kim obtained his M.D. from the Columbia University College of Physicians and Surgeons, and did his residency in internal medicine at Beth Israel Deaconess Medical Center and his fellowship in endocrinology at Brigham and Women’s Hospital. He was an instructor in medicine at Harvard Medical School before joining the faculty in Miami in 2009. His research interests include thyroid hormone action and metabolism, and his clinical practice focuses on thyroid cancer.
2006 ATA Grants
Determination of the Oncogenic Potential of PAX8/PPARy Fusion Protein (PPFP) and Elucidation of its Mechanism of Action in Follicular Thyroid Carcinoma
Honey V. Reddi, PhD
Mayo Clinic, Rochester, Minnesota
Honey V Reddi, PhD is a Director for Clinical Molecular Genetics at Prevention Genetics, LLC, Marshfield, WI. She obtained her PhD from the International Center for Biotechnology and Hamdard University, New Delhi, India in Molecular Virology and Life Sciences. Her post-doctoral research has focused on animals models for human disease, particularly cancer. As an Assistant Professor at the Mayo Clinic, Dr. Reddi’s work on delineating the mechanisms involved in the onset and progression of follicular thyroid cancer has resulted in several publications in peer-reviewed journals, review articles and a provisional patent. Dr. Reddi has received research grants from the American Thyroid Association, Wendy Will case Cancer Fund and the Fraternal Order of Eagles. She has been a member of the ATA since 2006 and has served on the annual meeting program committee from 2008-2010 and 2012-14.
Novel Thyroid Hormone Based Therapies for Human Cardiac Disease
Sara Danzi, PhD
NYU School of Medicine/North Shore University Hospital, Manhasset, New York
Dr. Sara Danzi received her B.S. in Biology, cum laude, from the State University of New York at Albany, an M.A. in Biology from Hofstra University in New York and M.Phil. and Ph.D. in Molecular Genetics from the City University of New York. She was awarded a post-doctoral fellowship from the American Heart Association and later received an American Heart Association Leadership Award. Dr. Danzi is a member of the American Thyroid Association and the American Heart Association Scientific Council on Basic Cardiovascular Sciences. She is currently Assistant Professor of Medicine at New York University School of Medicine and Director of the Molecular Endocrinology Laboratory at North Shore University Hospital Feinstein Institute for Medical Research. Her research is focused on the study of the basic transcriptional mechanisms that mediate the effects of thyroid hormone on the heart and cardiovascular system.
2005 ATA Grants
Generation and Analysis of Mice Deficient in the Thyroid Hormone Transporter MCT8 Heike Heuer, PhD Leibniz Institute for Age Research – Fritz Lipmann Institute, Jena, Germany
Heike Heuer is an independent research group leader and junior faculty member at the Leibniz Institute for Age Research/Fritz Lipmann Institute in Jena (Germany). She performed her PhD thesis at the Max Planck Institute for experimental Endocrinology in Hannover (Germany) followed by a postdoctoral training at the Center for Neurobiology & Behavior, Columbia University, NY. Her major research focus is to define the function of thyroid hormone transporters particularly in the brain by studying the respective mouse models. For her analysis of MCT8 deficient mice Dr Heuer has been awarded with an ATA research grant.
Mechanism of Regulation Gene Expression by Thyroid Hormone Receptors Through RNA Binding Pathways
Bin Xu, PhD
University of Michigan, Ann Arbor, Michigan
Bin Xu, Ph.D. Bin Xu, Ph.D. is a Research Assistant Professor in the Division of Metabolism, Endocrinology and Diabetes at the University of Michigan. Dr. Xu received his bachelor’s degree in 1986 and Ph.D. in 1996 from Ocean University of China. Dr. Xu continued at Ocean University of China as a Lecturer in Aquaculture since 1991 and became an Associate professor in 1996. Dr. Xu completed his postgraduate training in Biochemistry and Molecular Endocrinology from University of Michigan Medical School. Dr. Xu joined the faculty at the University of Michigan in 2001.
Dr. Xu’s research interests focus on regulation of gene expression by nuclear receptors (NRs) that are coordinated by direct or indirect interaction with RNA. He has characterized the novel RNA-binding domains in thyroid hormone receptors TR1 and TR2 steroidogenic factor 1 (SF-1) and PPAR. Dr. Xu’s recent research has been focused on the biological function of the non-coding RNA of steroid receptor RNA activator (SRA), and its coding protein (SRAP) in adipocytes, and the long term research interest is to understand the mechanism by which SRA/SRAP regulate fate of mesenchymal stem cells to the adipocyte lineage, and differentiation to white or brown adipocytes, and SRA/SRAP modulate insulin action and energy balance.
2004 ATA Grants
Fibroblast Immune Activation in Graves’ Disease
Raymond S. Douglas, MD, PhD
Harbor-UCLA Research and Education Institute, Torrance, California
Raymond S. Douglas is Associate Professor of Ophthalmology at the University of Michigan. He was formerly Assistant Professor of Ophthalmology at UCLA, Assistant Professor of Ophthalmology and Molecular Medicine at Harbor-UCLA Medical Center and Assistant Professor and Director of Orbital and Facial Plastic Surgery at the Greater Los Angeles Veterans Hospital. Dr. Douglas obtained his BSE, MD and PhD at the University of Pennsylvania, before completing his residency at the University of Pennsylvania and his fellowship at UCLA in Facial Plastic and Reconstructive Surgery. He specializes in orbital surgery, especially minimally invasive surgery, and decompressions for thyroid-associated eye disease. His research focus is Graves’ eye disease, autoimmune disease of the orbit and minimally invasive approaches to the orbit.
2003 ATA Grants
Tyrosine Kinase Receptor Oncogenes and Prostanoid Biosynthesis: Role of RET/PTC-induced Activation of Prostaglandin E2 Synthase in Thyroid Tumorigenesis
Jeffrey A. Knauf, PhD
University of Cincinnati College of Medicine, Cincinnati, Ohio ( now at MSKCC)
2002 ATA Grants
Type 2 Deiodinase-mediated Intracellular Thyrotoxicosis in Brown Adipocytes Is Critical for Energy Homeostasis and Adaptive Thermogenesis in Small Mammals
Antonio C. Bianco, MD, PhD
Brigham and Women’s Hospital, Boston, Massachusetts
Antonio C. Bianco, MD, PhD is a professor of medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Dr. Bianco obtained his M.D., PhD and clinical training in internal medicine and endocrinology in Sao Paulo, Brazil. Dr. Bianco is recognized as an authority in thyroid hormone metabolism and action, and his work has established the importance of the local control of thyroid hormone activation/inactivation via deiodination, as well as fundamental cellular and molecular properties of the deiodinases (D1, D2 and D3). Dr. Bianco’s work has helped elucidate the three-dimensional structure of the deiodinase-ubiquitination complex, demonstrating that hedgehog-mediated ubiquidation-deubiquidation controls local T3 production by affecting D2 dimerization. This constitutes a posttranslational on/off switch controlling thyroid hormone action in the settings of development, health and disease.
Targeted Overexpression of a Dominant Negative Insulin Growth Factor I (IGF-1) in Thyroid Follicular Cells in Vivo
Peter Kopp, MD
Northwestern University, Chicago, Illinois
Peter Kopp, MD is an Associate Professor in the Division of Endocrinology, and he serves as Director ad interim of the Center for Genetic Medicine at Northwestern University in Chicago. He obtained his MD degree from the University of Berne, Switzerland, where he also completed his training in Internal Medicine and Endocrinology. He is an ATA member since 1997 and has served on the Program Committee (Co-Chair in 2007), the Website Advisory Committee, the CME and Guidelines Committee, and the Publications Committee. He is currently a member of the Board of Directors and the Editor-in-Chief for the official journal of the American Thyroid Association, Thyroid. His principal research interests include congenital disorders of thyroid hormone synthesis, in particular Pendred’s syndrome. His clinical activities focus on patients with thyroid dysfunction and thyroid cancer.
2001 ATA Grants
Interleukin-12 and Autoimmune Thyroiditis
Patrizio Caturegli, MD
The Johns Hopkins University, Baltimore, Maryland
Patrizio Caturegli is an Assistant Professor of Pathology and Endocrinology and Director of the Hypophysitis Research Center at Johns Hopkins He graduated in 1980 from “La Querce College” in Florence, Italy (BA, Letters), and from the University of Pisa Medical School in 1987. He then completed a residency in Endocrinology also in Pisa (Italy), where he was Board-certified in 1992. Since 1993, Dr. Caturegli has been at Johns Hopkins. Here he completed a 3-year fellowship in immunology with Dr. Noel Rose and then a Residency in Pathology (certified by the American Board of Pathology in 1999). Since July 1999 he is a faculty member in the School of Medicine. His research focuses on the autoimmune diseases of the endocrine glands.
Role of Thyroid Hormone and TRAP230 in Dopaminergic Cell Survival and Differentiation
Robert Philibert, MD, PhD
Neuroscience Program, University of Iowa, Iowa City, Iowa
Robert Philibert MD, PhD is a Professor of Psychiatry and a member of both the Neuroscience and Genetics Program at the University of Iowa. He runs the Psychiatric Genetics Laboratory. Dr. Philibert began his career through the Medical Scientist Training Program at the University of Iowa and finished his psychiatry residency at the University of Iowa Hospitals and Clinics. After residency, he completed Pharmacology Research Associate Training Program Fellowship at the National Institutes of Health and then served for four years as a Senior Staff fellow. In 1998, he returned to the University of Iowa to establish a program in psychiatric genetics participates in the training of medical students and graduate students from a wide variety of disciplines including Neuroscience and Engineering. He has a broad research portfolio that includes 1) work on the effects of MED12 variation on transcriptional regulation and vulnerability to behavioral illness, 2) the role of DNA methylation and other epigenetic phenomena in moderating or mediating vulnerability to behavioral health outcomes, and 3) gene environment interactions.
2000 ATA Grants
Thyroid Hormone Regulation of Neural Differentiation
Yan-Yun Liu, , PhD
West LA VA Medical Center, Los Angeles, California
The ATA supported Yan-Yun (Kaitlyn) Liu’s, PhD research project in understanding the role of thyroid hormone neural differentiation of embryonic stem cells. Dr. Liu obtained B.S. from University of Jilin (China), M.S. from University of Beijing (China), and Ph.D. in Molecular Biology from University of Wales (U.K). She had two years of pre-doctorial training (1994-1996) in Endocrinology division in MD Anderson Cancer Center, Houston, UT, and her post graduate training was in Department of Medicine, David Geffen School of Medicine at UCLA (1997-2000). She became a research faculty member in 2001 at UCLA. In 2004, she became an assistant professor and in 2010 as associate professor. Although her current research interest has been shifted to thyroid hormone receptor isoform-specific actions in metabolism she still carries on some research in understanding the role of T3 in brain development.
The Role of AKT in the Thyroid Tumorigenesis Objectives
Matthew D. Ringel, MD
Washington Hospital Center, Washington DC
Matthew D. Ringel is a Professor of Medicine in the Division of Endocrinology and Metabolism at Ohio State University and Arthur G. James Comprehensive Cancer Center. He is the Director of the Endocrinology fellowship at Ohio State and is the co-director of the Ohio State Thyroid Cancer Unit. He currently is a member of the ATA Board of Directors, chair of the publication committee, editor of ATA’s SIGNAL and a Co-Chair of the 2009 Annual Meeting Program Committee. Dr. Ringel has an active clinical practice focused on thyroid cancer. His laboratory program focuses on defining the signaling pathways responsible for aggressive thyroid cancer behavior with a particular interest in the PI3 kinase/AKT pathway and other signaling cascades that regulate cell motility and invasion.
1999 ATA Grant
Regulation of Thyroid Hormone Responsive Genes by the Nuclear Receptor RIP 14
Ann Marie Zavacki, MD
Brigham and Women’s Hospital, Boston, Massachusetts
1998 ATA Grants
Molecular Mechanisms for Thyroid Hormone Regulation of Motor Neuronal Process Growth
Elzbieta Biesiada, PhD
Children’s Hospital of Orange County, Orange, California
Mutational and Functional Analysis of Candidate Susceptibility Genes in Graves’ Disease
Yaron Tomer, MD
Mount Sinai School of Medicine, New York, New York
Yaron M. Tomer is the Chief of the Hilda & J. Lester Gabrilove Division of Endocrinology, Diabetes and Bone Disease at Mount Sinai Medical Center, New York. Dr. Tomer received his medical degree from the Sackler School of Medicine at Tel Aviv University, Israel. He trained in Internal Medicine at Sheba Medical Center, Israel, and continued his training in Internal Medicine and in Endocrinology at The Mount Sinai Medical Center. Dr. Tomer’s research focuses on the immunogenetic, epigenetic, and environmental mechanisms causing thyroid autoimmunity, and type 1 diabetes. Dr. Tomer serves as a Special Editor of the journal, Thyroid, and serves on the editorial boards of Endocrinology, the Journal of Clinical Endocrinology and Metabolism, and Autoimmunity Reviews, among others. He is a member of the American Society for Clinical Investigation and a Fellow of the American College of Physicians, as well as the American College of Endocrinology. Dr. Tomer was the co-Chair of the program committee of the 2010 Spring Meeting of the American Thyroid Association, and served on the program committee of the 14th ITC held in Paris, France in 2010.
Thyroid Hormone Deficiency During Fetal and Early Childhood Development
Cary N. Mariash, MD
University of Minnesota, Minneapolis, Minnesota
Cary N. Mariash is currently the Medical Director and CEO of the Methodist Research Institute at Methodist Hospital, Indianapolis, Indiana. Formerly he was the director of the Division of Endocrinology and Diabetes at the University of Minnesota. He received his medical degree from the University of California at San Diego and his internal medicine and endocrinology training at the University of Minnesota. His research activities were NIH funded and focused on the role of thyroid hormone and carbohydrates on the regulation of lipogenesis in liver tissue. He currently supervises the basic science laboratories and the clinical research group at MRI. After the funding of the research project Dr. Mariash’s group received NIH funding based on the support from the ATA. The NIH grant was RO1-DK54060 titled “Thyroid Hormone Regulation of Brain Development”.
Thyroid Hormone Regulation of Mouse Somatostatin 5 Receptor Promoter
Whitney Woodmansee, MD
University of Colorado Health Science Center, Denver, Colorado
Whitney Woodmanse, MD is currently the Director of Clinical Neuroendocrine Program at Brigham & Womans’s Hospital. She completed her undergraduate and masters degree training at the University of Colorado, followed by medical school training, internal medicine residency and Endocrinology fellowship at the University of Colorado Health Sciences Center. Dr. Woodmansee has received many awards including a Student Honors and Research Committee Award in 1990 and 1991, the Robert H. Felix Award for best thesis in 1992, and a Clinical Scientist Development Award from the NIH.
1997 ATA Grants
Novel and Multi-Disciplinary Approach to Understanding the Physiological Regulation by Thyroid Hormone of the TRH Neurons in the Paraventricular Nucleus of the Hypothalamus
Stephanie L. Lee, MD, PhD
Tufts University, New England Medical Center, Boston, Massachusetts
Stephanie L. Lee is an Associate Professor of Medicine at the Boston University School of Medicine, Associate Chief of the Section of Endocrinology, Diabetes and Nutrition and Director of the Thyroid Nodule and Cancer Center. Dr. Lee has a PhD in Physiology/Pharmacology and a MD from the UC San Diego School of Medicine. She completed a Clinical Fellowship in Endocrinology and a Research Fellowship in Molecular Medicine at the New England Medical Center. The BMC Thyroid Nodule and Cancer Center is a comprehensive multidisciplinary center for the evaluation and treatment of patients with thyroid nodules and cancer that promotes translational research targeted to improve diagnosis and management of patients with thyroid disease. Dr. Lee coordinates all aspects of patient care for the diagnosis and treatment of thyroid diseases including ultrasonography and biopsy of thyroid masses and adenopathy, and formal dosimetry studies for life-threatening cases of thyroid cancer. Dr. Lee is recognized for her outstanding skills as a teacher and clinician with the 2007-9 Robert Evans Dawson Clinician Award from the Department of Medicine. She recently participated in writing the 2006 and the 2009 ATA evidence-based guidelines for the diagnosis and management of thyroid nodules and cancer.
Physiopathology of Brain Dysfunctions in Congenital Hypothyroidism
Jack Puymirat, MD, PhD and Robert Denver, PhD
CHU Laval Research Center, Sainte Foy, Canada
Dr. Jack Puymirat received his medical and scientific training from various different institutions in Paris France. In 1989 moved to Quebec Canada and is now currently the director of Human Genetics Unit located in the Centre Hospitalier Université Laval (CHUL) Research Center. He is also a Professor at Laval University (Department of Medicine) and scientific director of the Molecular Diagnosis Laboratory, CHUL in Quebec, Canada. He is a Neurologist member of the clinic of neuromuscular diseases at the Institut de réadaptation en déficience physique de Québec (IRDPQ) and CHUL. In 1999 he established the Jack Puymirat Research Lab. The aim of the lab is to study the mechanism responsible for Steinert myotonic dystrophy and to develop a genetic treatment for this disease. Other goals of the research unit are to develop genetic tests for several neuromuscular diseases and to offer genetic clinical tests and a neurogenetic disease database to scientists and clinicians.
Robert J. Denver, PhD is Professor of Molecular, Cellular and Developmental Biology (MCDB) and Professor of Ecology and Evolutionary Biology (EEB) at the University of Michigan, Ann Arbor. He earned his B.S. at Rutgers University in 1984 and the Ph.D. in 1989 from the University of California at Berkeley. He was appointed to the University of Michigan faculty in 1994. Professor Denver’s expertise is in hormone action in vertebrate development; molecular mechanisms of thyroid and corticosteroid receptor action in neural development; development and evolution of the neuroendocrine stress axis; mechanisms of developmental plasticity; endocrinology, ecology, and molecular biology of amphibian metamorphosis. He has published over one hundred scientific articles on these topics. He is president-elect of the International Federation of Comparative Endocrine Societies (IFCES), co-founder and first president of the North American Society for Comparative Endocrinology (NASCE), he served as a regular member of the Integrative and Clinical Endocrinology and Reproduction (ICER) Study Section, and he has served on four scientific advisory panels for the US EPA including the Endocrine Disrupter Screening Program and five grant review panels for the US NSF. He is associate editor of General and Comparative Endocrinology, Frontiers in Experimental Endocrinology, and Frontiers in Neuroendocrinology.
1996 ATA Grant
Early Sequel of Abnormal Intrauterine and Postnatal Thyroid Hormone Exposure
Joanne Rovet, PhD
The Hospital for Sick Children, Toronto, Canada
Joanne Rovet, PhD is Professor of Pediatrics and Psychology at University of Toronto and Senior Scientist in the Neuroscience and Mental Health Program at The Hospital for Sick Children in Toronto. She obtained her PhD from the University of Toronto and is a registered neuropsychologist in the Province of Ontario. Dr. Rovet has conducted pioneering studies on the role of thyroid hormone in the developing human brain and has used clinical/behavioral, electrophysiological and structural and functional neuroimaging approaches to do so. Her research on congenital hypothyroidism, maternal hypothyroidism, and hypothyroxinemia of prematurity provides critical key insights on when different human brain structures need thyroid hormone and has application to environmental thyroid disruptors. Dr. Rovet has consulted to the NIEHS, Environmental Defense League, and the California and US EPAs. She serves on the editorial boards of Thyroid, Child Neuropsychology, and Journal Developmental & Behavioral Pediatrics and was a member of the Endocrine Society’s Thyroid & Pregnancy Guidelines Committee and WHO team to establish iodine levels in pregnancy. She was awarded the Dewan Award from the Ontario Mental Health Foundation for her contributions to mental health in Ontario. Her research has been supported by grants from the Canadian Institutes of Health Research and March of Dimes. She has over 150 publications and is co-editor of a book on thyroid disorders in infancy and childhood.