These grants are selected by the ATA®Research Committee, approved by the ATA Board of Directors and awarded by the American Thyroid Association. Administrative management, marketing, financial and grant tracking support organized and provided by the ATA Headquarters’ office.
Research awardees are honored at the ATA Annual Meeting and on the ATA website with additional presentations and recognition on the ATA annual meeting program. Grant funding generously provided by Bite Me Cancer.
Dr. Wayne Miles of the Ohio State University Comprehensive Cancer Center was award a 2018 thyroid cancer research grant for the project titled: “Proteomic led discovery of essential genes in Medullary Thyroid Cancer” by the American Thyroid Association. Dr. Miles completed his undergraduate education at Massey University in New Zealand before moving to the University of Manchester (UK) for his graduate training. He then completed his Post-Doctoral fellowship at the Massachusetts General Hospital Cancer Center and Harvard Medical School researching the mechanisms that enable cancer cells lacking the Retinoblastoma 1 (RB) tumor-suppressor gene to survive. He then moved to the Ohio State University Comprehensive Cancer Center in 2016. Dr. Miles’ research focuses on understanding how loss of the Retinoblastoma 1, RB, tumor-suppressor gene and its upstream regulators contribute to cancer growth. More recently, his research has expanded to investigate the roles of RB-inactivation in Medullary Thyroid Cancer, as this disease represents a unique place to study RB-regulation. This is because: (1) RB-inactivation caused by CDKN2C loss is the strongest prognostic marker of poor outcome for MTC patients and (2) RB1-/- mice develop aggressive MTC. Building on Dr. Miles’ proteomic profiling of MTC cells lines. In this project, the Miles lab will couple large scale omics profiling and CRISPR to determine; (1) the composition of the murine MTC tumor proteome and (2) which proteins are essential for human MTC cell line survival.
2017 Bite Me Cancer
Novel Alternative Pathways and Mutational Hotspots in Papillary Thyroid Cancer with Acquired Resistance to BRAF Inhibitors
Brian P Danysh, PhD – The University of Texas MD Anderson Cancer Center, Houston TX
Dr. Brian Danysh of the University of Texas MD Anderson Cancer Center was awarded a 2017 thyroid research grant for the project titled “Novel Alternative Pathways and Mutational Hotspots in Papillary Thyroid Cancer with Acquired Resistance to BRAF Inhibitors” by the American Thyroid Association. The grant is awarded by the ATA Research Committee, chaired by Dr. Motoyasu Saji, approved by the ATA Board of Directors and administered by the ATA Headquarters’ office. Administrative and grant tracking support provided by the ATA. Research awardees are honored at the ATA Annual Meeting and on the ATA website with additional presentations and recognition on the ATA annual meeting program. Grant funding was generously provided by Bite Me Cancer. Dr. Danysh’s earliest contributions to science emerged from the confluence of his interests in cellular and extracellular matrix biology, which he acquired during his graduate studies at the University of Delaware and his interests in translational cancer research, which he developed during his postdoctoral trainings at Rice University and MD Anderson Cancer Center. Throughout his trainings, he has cultivated collaborations with scientists and clinicians to develop novel approaches to scientific and therapeutic challenges. At Rice University, he used nanotechnology to exploit aberrant mucin expression in endometrial carcinoma, delivering targeted nanoparticles and laser irradiation to selectively destroy cancer cells. The project, which required a collaboration with physicists, demonstrated mucins as promising therapeutic targets. His current research involves a collaboration with clinicians and examines mechanisms of acquired inhibitor resistance. He is studying the genetic and epigenetic modifications that occur in PTC cells that allow them to escape sensitivity to BRAF inhibitors. His most recent publication describes BRAF(V600E) inhibitor resistance through acquisition of a KRAS(G12D) mutation following long-term vemurafenib treatment. Recent findings have drawn his attention to alternative mechanisms outside the RAF-MEK-ERK and PI3K-AKT pathways, which is the focus of his funded thyroid cancer research project. His ultimate goal is to discover novel therapeutic targets to recurrent metastatic thyroid cancer.
Dr. Irene M. Min received her BS in Biology from Sogang University, Seoul, South Korea in 1997, and M.Phil from the Department of Physiology, from Cambridge University, England, in 1998. She earned her PhD in Genetics from Tufts University School of Medicine in Boston, MA in 2004. She has trained with a leader in stem cell biology field at Harvard Medical School, Boston and completed a postdoctoral fellowship at Cornell University, Ithaca, NY in 2012, where she was awarded with the American Cancer Society postdoctoral fellowship for two years. An experienced basic research scientist with a focus in stem cell biology, genetics and genomics, Dr. Min’s main research interests are understanding transcription regulation in stem cells and cancer, and developing therapeutic tools to target specific pathway to examine the functional consequences in cell growth and to further advance related technologies for diagnostics and therapeutics. She is widely-published in prestigious journals such as Cell Stem Cell, Genes and Development, and Immunity and has co-authored a book chapter in Advances in Immunology. Press Release
2015 Bite Me Cancer
Evaluation of a gene expression classifier derived from The Cancer Genome Atlas (TCGA) analysis to predict clinical behavior of BRAF-mutant thyroid carcinomas
Laura Boucai, MD– Memorial Sloan-Kettering Cancer Center, New York, NY
Laura Boucai, MD, MS is a physician-scientist at Memorial Sloan Kettering Cancer Center focused on endocrine tumors and malignancies. Her specific interest is in thyroid cancer and her goal is to advance the knowledge and treatment options for patients with this condition. Dr. Boucai attended medical school at University of Buenos Aires, in Argentina. She then underwent her Internal Medicine residency training at Cornell University and completed an Endocrinology fellowship at Albert Einstein College of Medicine. Under the mentorship of Dr. Martin I. Surks, she studied the effects of age, race, and gender on the TSH distribution. Following her interests in thyroid diseases, she joined the clinical faculty at Memorial Sloan Kettering Cancer Center, where she serves as an instrumental member of a multi-disciplinary team of physicians dedicated to understanding the pathogenesis and advancing the knowledge of this condition. Dr. Boucai is interested in studying and promoting risk-adapted therapeutic strategies in patients with thyroid cancer with the ultimate goal of developing interventions that reduce harm without changing cancer prognosis. Press Release
2014 Bite Me Cancer
Immune Markers in Medullary Thyroid Cancer (MTC) and Their Clinical Significance
Ramona Dadu, MD – The University of Texas M. D. Anderson Cancer Center, Houston, TX
Dr. Ramona Dadu will transition to an Assistant Professor position in the Department of Endocrine Neoplasia & Hormonal Disorders at M.D. Anderson Cancer Center starting July 2014. Dr. Dadu received her MD degree from Iuliu Hatieganu University of Medicine and Pharmacy in Romania, where she also trained in Clinical Pharmacology and Toxicology. After graduation from Internal Medicine residency in Connecticut, she joined Baylor College of Medicine/M.D. Anderson Cancer Center endocrinology fellowship program. During this time, she also matriculated into the Clinical Scientist Training Program where she received extensive training in grant writing, conduct of research, and biostatistics. For the last 2 years of her training, she focused on thyroid cancer research under the mentorship of Dr. Maria E. Cabanillas. She is the author of several peer reviewed publications related to thyroid cancer and received the Women in Endocrinology Young Investigator Award in 2014. She is the recipient of the ATA grant for her research project entitled “Immune markers in medullary thyroid cancer and their clinical significance”. Dr. Dadu has already started collaborations that have enabled her to expand her expertise beyond Endocrinology to Immunology in order to begin to examine the role of immune system in medullary thyroid cancer. Her long term goal is to become an independent investigator and leader in the field of advanced thyroid cancer, with specific focus in immune based therapies. Press Release